Cardiologists Team with Other Specialists to Combat Sleep Apnea

	To address patients with sleep apnea, Desert Cardiology in Tucson, Ariz., added a certified sleep center and a pulmonologist to the practice.

The ever-increasing evidence linking obstructive sleep apnea (OSA) to cardiovascular conditions has spurred cardiologists to form multidisciplinary teams to better treat their patients suspected of having OSA.

What we know

“The medical profession as a whole over the last 15 years was relatively unaware of the implications of sleep apnea,” says Virend K. Somers, MD, PhD, director of the Sleep and Cardiovascular Clinical Research Units at the Mayo Clinic in Rochester, Minn. Somers was the lead author of an expert consensus document on OSA, spearheaded by the American Heart Association and the American College of Cardiology (J Am Coll Cardiol 2008;52:686–717).

In the document, Somers and colleagues agreed that much needs to be learned about the relationship between OSA and cardiovascular events. They concluded that a “relative lack of definitive outcomes data to guide clinical practice necessitates a highly individualized approach to evaluation and management of those patients with comorbid cardiovascular disease and sleep apnea.”

In an effort to further outcomes data, Julio A. Chirinos, MD, director of noninvasive cardiac imaging at the Philadelphia VA Medical Center, is the chief investigator in the enrolling COSA (Cardiovascular Effects of Obstructive Sleep Apnea) study. The research is examining whether treatment of OSA with continuous positive airway pressure (CPAP) decreases heart disease risk factors, including inflammation (C-reactive protein) and insulin resistance. Researchers also are analyzing DNA to look for an association between apoE genotypes and both dyslipidemia and inflammation.

Patients will be randomized to CPAP alone, weight loss alone or a combination of the two therapies. "We know there is a risk of cardiovascular disease when someone has OSA. We don't yet know whether those risk factors will decrease if we treat the apnea," Chirinos says.

OSA affects more men than women and remains undiagnosed in 80 percent of patients. As the evidence of the potential harm of sleep apnea accrues, more cardiologists have begun working with other specialists to recognize and treat OSA early. In 2008, Desert Cardiology in Tucson, Ariz., added a certified sleep center and a pulmonologist to the practice after it realized just how many of their cardiology patients exhibited signs of sleep apnea or had been previously diagnosed with the disorder. “If you have a soft modicum of suspicion and ask the right questions, you can discover in your own practice those who should be tested,” says Greg Koshkarian, MD, a cardiologist with the group, who sees an estimated 300 patients per month. Of those 300, sleep studies are ordered for 5 to 10 percent. The addition of the sleep center has provided better patient care, he says.

Home testing

Koshkarian calls a full sleep study in a lab the “gold standard” because it records brain waves, heart waves, chest wall movements, oxygen saturation and rapid eye movement. Not all patients are candidates for lab study, however, and sleep specialists are increasingly sending patients home with portable testing monitors.

BlueSleep, a sleep apnea center in downtown Manhattan, uses a portable Holter-oximeter device to diagnose patients in their home, says Jordan C. Stern, MD, founder and director of the center. Compared to a sleep lab that is equipped with a fixed number of beds, home sleep testing allows staff at the center to test a larger number of patients—three to 10 per week, says Stern.

Sam Kuna, MD, chief of the pulmonary, critical care and sleep section at the Philadelphia VA, also sends patients home with a portable device. “For our sleep apnea patient population, we feel quite comfortable that home testing and in-lab testing are equivalent,” he says. In fact, Kuna presented a study at the 2010 American Thoracic Society meeting showing no difference between the two approaches.

Kuna and colleagues evaluate about 50 patients a month for sleep apnea via home monitors. Many of his referrals come from Chirinos. “I would not consider sending my patients home with a sleep monitor. I leave that up to a qualified sleep specialist, whether he or she wants to perform in-lab testing or home testing,” Chirinos says.

The VA uses a type III portable monitor to record patients’ respiratory signals. This monitor allows Kuna to distinguish between OSA and central apnea. The home testing is now reimbursed by Medicare. “It’s important to realize this isn’t a test to simply identify sleep apnea,” he says. “This is a management pathway. There has to be adequate expertise to manage these patients and to recognize who qualifies for testing, how to interpret the results, how to manage the patients after the results come in and how to continue to follow the patients.”

In Kuna’s study, he retested patients in the sleep lab whose home tests were negative. For various reasons, false negatives occur, he says. “As you increase the application of the portable monitors to a wider population, you will potentially have more negative studies coming back from the home. Again, in symptomatic patients, you will need to have additional evaluation to feel confident you haven't missed anything. If portable monitors really take off, it will just bring more people into the sleep lab,” he says.

While Kuna’s patient population has a high pretest probability of OSA, the patient population of Desert Cardiology is more heterogeneous. Koshkarian’s group prefers the more comprehensive overnight test in the lab. While a night in the sleep lab may be more comprehensive, costs and care associated with the home test systems may be more reasonable. The home unit used at BlueSleep costs the center about $1 to $2 per study—the cost of the batteries and the skin sensors. Additionally, other devices charge a fixed amount per study and a one-time fee for use.

Reimbursement

CMS recently approved reimbursement for type II, III and IV home sleep testing devices, which should spur their wider use. Type II and III devices are covered when used in patients who have “clinical signs and symptoms indicative of OSA,” according to CMS. Type IV devices must measure with at least three or more channels. CMS requires those who were diagnosed with sleep apnea and referred to CPAP treatment to have a follow-up visit at a sleep clinic within 90 days of the diagnosis to ensure that the equipment is functioning properly.

Stern suggests that payors eventually will allow primary care physicians (PCPs) to perform sleep studies to diagnose sleep apnea. “The PCPs are in the best position to diagnose sleep apnea because often the first doctor a patient sees is a PCP, not a specialist,” he says.

Because sleep apnea is treated by a combination of specialists—ear, nose and throat doctors, nutritionists, pulmonologists, dental specialists and psychiatrists—“there are certainly turf issues that exist,” says Stern.

The bottom line, however, is the increasing awareness of the link between OSA and cardiovascular disease, which gives cardiologists the chance to become integral partners with other specialists to deliver optimal care to their patients.