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Gene-editing therapy delivers 'unprecedented' results | SCAI fights for interventional cardiologists | AI for STEMI detection

News You Need to Know Today
Gene-editing therapy delivers 'unprecedented' results | SCAI fights for interventional cardiologists | AI for STEMI detection
Wednesday, November 12, 2025
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Today's News and Trends

‘Unprecedented’: Single dose of new gene-editing therapy lowers cholesterol, triglycerides

First-in-human data suggest the therapy, CTX310, could be a breakthrough for patients with lipid disorders.

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A new gene-editing therapy has been tested on humans for the first time, resulting in a significant reduction in their low-density lipoprotein (LDL) cholesterol that could potentially last for decades. The study’s authors presented these early results at the AHA 2023 meeting.
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‘Unprecedented’: Single dose of new gene-editing therapy lowers cholesterol, triglycerides

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A new gene-editing therapy has been tested on humans for the first time, resulting in a significant reduction in their low-density lipoprotein (LDL) cholesterol that could potentially last for decades. The study’s authors presented these early results at the AHA 2023 meeting.
First-in-human data suggest the therapy, CTX310, could be a breakthrough for patients with lipid disorders.
READ MORE >

SCAI fighting for interventional cardiologists amid challenging payment policies

SCAI President Srihari Naidu, MD, detailed some of the challenges interventional cardiologists face as reimbursements keep declining. The group has been building new partnerships with other medical societies to strengthen its influence in Washington. 

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 SCAI President Srihari S. Naidu, MD, professor of medicine at New York Medical College, explained some of the key payment issues interventional cardiologists are facing amid declining Medicare reimbursements.
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SCAI fighting for interventional cardiologists amid challenging payment policies

Share on Twitter Share on Facebook Share on Linkedin
 SCAI President Srihari S. Naidu, MD, professor of medicine at New York Medical College, explained some of the key payment issues interventional cardiologists are facing amid declining Medicare reimbursements.
SCAI President Srihari Naidu, MD, detailed some of the challenges interventional cardiologists face as reimbursements keep declining. The group has been building new partnerships with other medical societies to strengthen its influence in Washington. 
READ MORE >

AI dramatically improves the detection of severe heart attacks

Researchers put an advanced AI model to the test, using it to evaluate the ECG results of more than 1,000 patients. It performed quite well. 

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artificial intelligence AI heart cardiology
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AI dramatically improves the detection of severe heart attacks

Share on Twitter Share on Facebook Share on Linkedin
artificial intelligence AI heart cardiology
Researchers put an advanced AI model to the test, using it to evaluate the ECG results of more than 1,000 patients. It performed quite well. 
READ MORE >

Featured Articles

New pill lowers cholesterol for patients already on statins—no needles required

The new drug from Merck was linked to several benefits for patients who are already on statins. If an oral PCSK9 inhibitor gains FDA approval, it could be a game-changer for the field of preventive medicine. 

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cholesterol.png
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New pill lowers cholesterol for patients already on statins—no needles required

Share on Twitter Share on Facebook Share on Linkedin
cholesterol.png
The new drug from Merck was linked to several benefits for patients who are already on statins. If an oral PCSK9 inhibitor gains FDA approval, it could be a game-changer for the field of preventive medicine. 
READ MORE >

Interventional cardiology showing more interest in endovascular procedures

Sahil Parikh, MD, said it was clear at TCT 2025 that the specialty is getting more and more involved with endovascular procedures for stroke, pulmonary embolism and peripheral artery disease.

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Sahil Parikh, MD, director of endovascular services, Columbia University Irving Medical Center, associate professor of medicine at Columbia University, and a program director for the Transcatheter Cardiovascular Therapeutics (TCT) meeting, explains the growing focus in interventional cardiology on endovascular procedures for stroke, pulmonary embolism, peripheral artery disease and renal denervation.
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Interventional cardiology showing more interest in endovascular procedures

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Sahil Parikh, MD, director of endovascular services, Columbia University Irving Medical Center, associate professor of medicine at Columbia University, and a program director for the Transcatheter Cardiovascular Therapeutics (TCT) meeting, explains the growing focus in interventional cardiology on endovascular procedures for stroke, pulmonary embolism, peripheral artery disease and renal denervation.
Sahil Parikh, MD, said it was clear at TCT 2025 that the specialty is getting more and more involved with endovascular procedures for stroke, pulmonary embolism and peripheral artery disease.
READ MORE >

FDA clears new-look robotic system from Stereotaxis

GenesisX represents the company’s most accessible robotic system to date. It requires no room shielding or structural anchoring, for example, and the size has been significantly reduced.

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Stereotaxis GenesisX
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FDA clears new-look robotic system from Stereotaxis

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Stereotaxis GenesisX
GenesisX represents the company’s most accessible robotic system to date. It requires no room shielding or structural anchoring, for example, and the size has been significantly reduced.
READ MORE >

Confirmed: AI software from Heartflow flags high-risk coronary plaques for cardiologists

Researchers tracked data from nearly 8,000 patients evaluated with Heartflow's FDA-cleared Plaque Analysis software. Overall, the technology's Plaque Staging feature was found to provide significant value during the diagnosis and management of these patients.

READ MORE >
HeartFlow Plaque Analysis Example
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Confirmed: AI software from Heartflow flags high-risk coronary plaques for cardiologists

Share on Twitter Share on Facebook Share on Linkedin
HeartFlow Plaque Analysis Example
Researchers tracked data from nearly 8,000 patients evaluated with Heartflow's FDA-cleared Plaque Analysis software. Overall, the technology's Plaque Staging feature was found to provide significant value during the diagnosis and management of these patients.
READ MORE >

‘Father of ECMO’ Robert H. Bartlett remembered for his passion, kindness

Robert H. Bartlett, MD, was a pioneer surgeon who helped develop the world's first ECMO technology. He died at the age of 86 following a long illness. 

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Robert H. Bartlett, MD
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‘Father of ECMO’ Robert H. Bartlett remembered for his passion, kindness

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Robert H. Bartlett, MD
Robert H. Bartlett, MD, was a pioneer surgeon who helped develop the world's first ECMO technology. He died at the age of 86 following a long illness. 
READ MORE >

In Case You Missed It

Medicare now covers renal denervation for patients with uncontrolled hypertension

This decision expands access to renal denervation to many more patients throughout the United States. Recor Medical and Medtronic both gained FDA approval for their RDN systems in 2023, and other vendors are actively developing their own treatment options.

READ MORE >
The U.S. Food and Drug Administration (FDA) has approved Recor Medical’s Paradise Ultrasound Renal Denervation (RDN) system for uncontrolled hypertension. The Recor system gained FDA clearance in November 2023.
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Medicare now covers renal denervation for patients with uncontrolled hypertension

Share on Twitter Share on Facebook Share on Linkedin
The U.S. Food and Drug Administration (FDA) has approved Recor Medical’s Paradise Ultrasound Renal Denervation (RDN) system for uncontrolled hypertension. The Recor system gained FDA clearance in November 2023.
This decision expands access to renal denervation to many more patients throughout the United States. Recor Medical and Medtronic both gained FDA approval for their RDN systems in 2023, and other vendors are actively developing their own treatment options.
READ MORE >

Clinical trials paused due to heart patient’s hospitalization

Intellia Therapeutics paused clinical trials for ATTR-CM and ATTR-PN after a patient was hospitalized due to a significant liver injury. 

READ MORE >
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Clinical trials paused due to heart patient’s hospitalization

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Intellia Therapeutics paused clinical trials for ATTR-CM and ATTR-PN after a patient was hospitalized due to a significant liver injury. 
READ MORE >

First-in-human data highlight IVL’s potential to treat more challenging lesions

Shockwave Medical and FastWave Medical have shared new first-in-human data on their advanced IVL offerings. Both companies are focused on addressing difficult-to-cross lesions that often cause problems for cardiologists.

READ MORE >
Shockwave Medical IVL
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First-in-human data highlight IVL’s potential to treat more challenging lesions

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Shockwave Medical IVL
Shockwave Medical and FastWave Medical have shared new first-in-human data on their advanced IVL offerings. Both companies are focused on addressing difficult-to-cross lesions that often cause problems for cardiologists.
READ MORE >

In Other News


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