Peripheral Artery Disease

Peripheral artery disease (PAD) involves atherosclerosis mainly in the extremities, especially in the legs and feet that lead to ischemia. Untreated, PAD can progress to critical limb ischemia (CLI), also called chronic limb-threatening ischemia (CLTI), which will lead to foot or leg amputation. The mortality rate for these CLI amputees is 70% within three years. There is currently an epidemic of PAD and CLI in the U.S. The majority of patients are defined by health disparities concentrated in the Black, Latino, Native American populations in both rural and low-income urban areas. A large number of PAD patients have other comorbities, with diabetes being one a primary issue.

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USPSTF: Evidence insufficient to assess benefits, harms of using ABI to screen for PAD

The U.S. Preventive Services Task Force (USPSTF) issued a Grade I recommendation for screening peripheral artery disease (PAD) and cardiovascular disease (CVD) risk with the ankle-brachial index (ABI), indicating current evidence is insufficient to recommend screening without signs or symptoms of disease.

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FDA approves more lengths of Medtronic’s drug-coated balloon for PAD

The 200 and 250 millimeter lengths of Medtronic’s IN.PACT Admiral drug-coated balloon gained FDA approval to treat long superficial artery (SFA) lesions in patients with peripheral artery disease (PAD), the company announced June 15.

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Exercise interventions for PAD may require personal support

A randomized trial published April 24 in JAMA suggests patients with lower-extremity peripheral artery disease (PAD) can’t be expected to improve walking performance on their own, even with the aid of wearable activity trackers and telephone coaching sessions.

IN.PACT Admiral Demonstrates Consistent and Durable Outcomes in New Two-Year Japan Data and IN.PACT Global Critical Limb Ischemia Cohort Analysis

DUBLIN and LEIPZIG — January 30, 2018 — Medtronic plc (NYSE: MDT) today added to its robust body of clinical evidence supporting the IN.PACT(TM) Admiral(TM) drug-coated balloon (DCB) with new presentations that demonstrated durable and consistent clinical outcomes in peripheral artery disease (PAD).

Higher statin doses tied to fewer deaths, amputations in PAD patients

High-intensity statin therapy for peripheral artery disease (PAD) patients reduces the risk of lower-extremity amputations by one-third and the risk of mortality by 26 percent, a new study found. However, the lipid-lowering drugs remain underutilized in the PAD population despite their guideline-recommended use.

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Vascular disease research gets $15M kickstart from AHA

Four medical centers have been awarded a cumulative $15 million by the American Heart Association (AHA) as part of an effort to expand current research on vascular disease, the AHA announced in a statement Friday.

Self-expanding stents outperform balloon-expandable stents for iliac artery disease

Self-expanding (SE) stents proved more effective than balloon-expandable (BE) stents for the treatment of atherosclerosis of the iliac arteries and are thus recommended for affected patients, according to researchers who recently compared the two versions among a large group of patients being treated in northern Europe.  

FDA Grants Market Clearance to Ra Medical Systems for New Peripheral Artery Disease Treatment

In an effort to battle Peripheral Artery Disease (PAD), the leading cause of limb amputations, the Food and Drug Administration (FDA) announced today that it has granted market clearance to Ra Medical Systems, makers of excimer lasers and catheters for cardiovascular and dermatological diseases, for the Company’s groundbreaking DABRA System.

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