Poor post-PCI TIMI flow grades linked to excess mortality in women with STEMI

Delay to hospital presentation and suboptimal post-percutaneous coronary intervention (PCI) TIMI flow grades are both independently associated with excess mortality in women who suffer ST-segment elevation myocardial infarction (STEMI), according to a study that sought to better define the disproportionate sex gap in STEMI mortality.

87 lots of losartan recalled as FDA investigation reveals more impurities in BP drugs

An ongoing FDA investigation of generic angiotensin II receptor blocker (ARB) drugs used to treat hypertension and heart failure found higher-than-acceptable levels of the carcinogen N-Nitroso-N-methyl-4-aminobutyric acid (NMBA) in recent batches of losartan potassium tablets, prompting a voluntary recall of 87 lots, the agency announced March 1. NMBA is the third different carcinogenic impurity recently discovered in ARBs.

Overlapping surgery is safe—except in high-risk and CABG patients

Overlapping surgery—in which a surgeon moves from one procedure to the next before the first is finished, leaving junior surgeons and trainees to wrap up the noncritical portions of the surgery—isn’t associated with increased mortality or post-op complications in most cases. But, according to a study published in JAMA Feb. 26, it can raise the risk of adverse events in high-risk patients and those undergoing coronary artery bypass graft (CABG) surgery.