Clinical Research

A late-breaking science presentation at the annual TCT interventional cardiology meeting.

Late-breaking clinical trials at TCT 2023

Here is a list of all the late-breaking clinical trials being presented at the Transcatheter Cardiovascular Therapeutics (TCT) 2023 annual meeting Oct. 23-26, 2023, in San Francisco.

The central figure from the study "Predictors and Variation in Cardiac Rehabilitation Participation After Transcatheter Aortic Valve Replacement study 2023," showing the wide variation in the percentage of patients who receive post-TAVR rehab among TAVR patients in Michigan.

Less than one-third of TAVR patients enter cardiac rehab

Only about 30% of patients who underwent TAVR in Michigan participated in cardiac rehabilitation within 90 days after discharge.

Direct acyclic graph representing a causal structural model of mediation of the association between obesity in early pregnancy and cardiovascular disease (CVD) risk factors after delivery. E indicates exposure; GDM, gestational diabetes; HDP, hypertensive disorders of pregnancy; M, mediators; O, outcome; PTB, preterm birth; SBP, systolic blood pressure; SGA, small-for-gestational-age birth; and TC, total cholesterol. *Variable included in sensitivity analysis.

Pregnancy complications increase and unmask cardiovascular risks in obese patients in NIH study

New research is providing a broader understanding of how cardiovascular disease risk manifests following pregnancy. Having obesity before and during early pregnancy appears to be a strong indicator of risk for developing future cardiovascular disease and was significantly linked with adverse outcomes during pregnancy.

Specialists at Cleveland Clinic treated a hypertrophic cardiomyopathy patient with a new gene therapy from Tenaya Therapeutics

Cleveland Clinic treats first patient with new gene therapy for hypertrophic cardiomyopathy

Researchers hopes this first-in-class gene therapy, known as TN-201, can restore the patient’s MYBPC3 levels and eventually lead to disease reversal.

No, a popular blood pressure medication does not increase heart failure risk, new research confirms

Dihydropyridines such as amlodipine have been the topic of some debate in recent months due to fears they lead to significant side effects. 

AI artificial intelligence stethoscope doctor

AI model detects multiple heart issues in a single 10-second audio clip

The advanced algorithm achieved a sensitivity of 93% and specificity of 98%. It was trained to identify up to five different valvular diseases at the same time from a single audio clip.

Patisiran, marketed under the name Onpattro

FDA chooses not to approve patisiran for treating ATTR cardiomyopathy

The announcement came just weeks after an FDA subcommittee voted in favor of approval. 

Video of Christina Albert, MD, MPH chair, Department of Cardiology, Cedars-Sinai, explaining the changing approaches to sudden cardiac arrest. #SCA #SCD #ESC #ESC23 #ESC2023

Changing approaches to the treatment of sudden cardiac arrest

Preventing sudden cardiac arrest involves managing risk factors such as hypertension, hyperlipidemia and diabetes. We spoke to Christine Albert, MD, about this and much more at ESC 2023.

Around the web

Ron Blankstein, MD, professor of radiology, Harvard Medical School, explains the use of artificial intelligence to detect heart disease in non-cardiac CT exams.

Eleven medical societies have signed on to a consensus statement aimed at standardizing imaging for suspected cardiovascular infections.

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