Heart Failure

Heart failure occurs when the heart cannot pump as much blood as the body requires. This ineffective pumping can lead to enlargement of the heart as the myocardium works harder pump the same amount of blood. Heart failure may be caused by defects in the myocardium, such as an a heart attack infarct, or due to structural issues such as severe heart valve regurgitation. Heart failure can be divided into HF with preserved ejection fraction (HFpEF), and HF with reduced ejection fraction (HFrEF). The disease is further divided into four New York Heart Association (NYHA) classes. Stage IV heart failure is when the heart is completely failing and requires a heart transplant or hemodynamic support from a left ventricular assist device (LVAD).

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FDA approves sotagliflozin, the new heart failure drug from Lexicon Pharmaceuticals

The drug, which should be available by the end of June, will be marketed under the name Inpefa.

artificial intelligence robot evaluates healthcare data

AI organizes heart failure patients into 5 distinct groups, helping cardiologists manage care

Researchers used multiple AI models to evaluate EHR data from more than 322,000 heart failure patients. By identifying these subtypes, the group thinks clinicians could perform better risk assessments and make more informed treatment decisions. 

Cleveland Clinic cardiologists implant Impulse Dynamics device for first time in the world

Cleveland Clinic cardiologists make history, become first in world to implant new heart failure device

Bruce Wilkoff, MD, director of cardiac pacing and tachyarrhythmia devices at Cleveland Clinic, said the new device could be "an important advancement for heart failure patients."

FDA expands dapagliflozin approval to cover all heart failure patients

The FDA has previously approved the SGLT2 inhibitor in patients with HFrEF, but not HFmrEF or HFpEF

American Heart Association awards researchers $15M to study stress-related CVD

Teams from three universities have received four-year research grants to examine the relationship between chronic stress and CVD. Each team plans to study the issue from a different angle.

Magenta Medical Elevate Heart Pump

Medical device company raises $55M for new percutaneous heart pump

The device, described as the "world's smallest heart pump," has received the FDA's breakthrough device designation for two indications. 

CVRx Barostim illustration

CVRx ‘thrilled’ with Q1 performance as Barostim use continues to increase

The company has seen significant improvements in revenue and the number of centers actively using its technology.

Laser speckle imaging captures details of blood vessels in a beating donor transplant heart outside the body for viability evaluation. Image from Plyer et al., doi 10.1117/1.JBO.28.4.046007

Laser technology may help determine viability of transplant hearts

A new laser imaging technology may be able to determine which donor hearts are viable for transplant and which will result in poor outcomes, without the need for coronary angiography or use of contrast agents that can damage an explanted heart.

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Use of AI opportunistic screening in CT for cardiovascular disease

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