Structural Heart Disease

Structural heart diseases include any issues preventing normal cardiovascular function due to damage or alteration to the anatomical components of the heart. This is caused by aging, advanced atherosclerosis, calcification, tissue degeneration, congenital heart defects and heart failure. The most commonly treated areas are the heart valves, in particular the mitral and aortic valves. These can be replaced through open heart surgery or using cath lab-based transcatheter valves or repairs to eliminate regurgitation due to faulty valve leaflets. This includes transcatheter aortic valve replacement (TAVR). Other common procedures include left atrial appendage (LAA) occlusion and closing congenital holes in the heart, such as PFO and ASD. A growing area includes transcatheter mitral repair or replacement and transcatheter tricuspid valve repair and replacement.

Transradial approach gains momentum, and for good reason

In his practice, Sunil V. Rao, MD, uses the transradial approach for interventional cath procedures for about 85 percent of his patientswhich is everyone who can safely undergo the technique. But Rao is an anomaly in the U.S., and even within his own institution.

CMS modifies DRG validation in 2010, based on RAC input

In response to feedback from the Recovery Audit Contractors (RACs), providers/suppliers and their associations, the Centers for Medicare & Medicaid Services (CMS) has modified the additional documentation request limits for diagnosis-related group (DRG) validation purposes in the RAC program for FY2010.

Novartis scores Corthera and its heart failure drug for up to $620M

Novartis is seeking to acquire biopharmaceutical company Corthera, along with its promising drug candidate relaxin, a naturally occurring human peptide used in the treatment of acute decompensated heart failure, for up to $620 million.

Nasdaq to delist Via Pharmaceuticals

Via Pharmaceuticals, a developer of biotechnology compounds for the treatment of cardiovascular and metabolic disease, received a written notice on Dec. 29, 2009, from the listing qualifications staff of the Nasdaq Stock Market, stating that trading of its common stock would be suspended prior to the open of business on Jan. 4, 2010. Nasdaq is initiating procedures to delist Vias common stock.

Medicines pays up to $427M for Pfizers plaque drug

The Medicines Company has gained exclusive global licensing to Pfizers ApoA-I Milano, which is a naturally occurring variant of a protein found in high-density lipoprotein that has the potential to reverse atherosclerotic plaque development and reduce the risk of coronary events in patients with acute coronary syndrome.

Survey: Additional diabetes drugs, DPP-IV inhibitors needed

A survey conducted by market research company Decision Resources found that 70 percent of physicians believe that additional diabetes drugs with novel mechanisms of action are needed, while 15 percent urged that additional DPP-IV inhibitors need to be developed.

AstraZeneca, UVa align to slow atherosclerotic plaque development

AstraZeneca has partnered with the University of Virginia (UVa) to develop new treatments to fend off coronary artery disease and peripheral vascular disease.

Merck snags biotechnology company focused on heart disease, stroke

Merck has secured a deal with contract manufacturing company Avecia to acquire its biologics business. The financial aspects of the transaction have not been disclosed.

Around the web

Ron Blankstein, MD, professor of radiology, Harvard Medical School, explains the use of artificial intelligence to detect heart disease in non-cardiac CT exams.

Eleven medical societies have signed on to a consensus statement aimed at standardizing imaging for suspected cardiovascular infections.

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