Structural Heart Disease

Structural heart diseases include any issues preventing normal cardiovascular function due to damage or alteration to the anatomical components of the heart. This is caused by aging, advanced atherosclerosis, calcification, tissue degeneration, congenital heart defects and heart failure. The most commonly treated areas are the heart valves, in particular the mitral and aortic valves. These can be replaced through open heart surgery or using cath lab-based transcatheter valves or repairs to eliminate regurgitation due to faulty valve leaflets. This includes transcatheter aortic valve replacement (TAVR). Other common procedures include left atrial appendage (LAA) occlusion and closing congenital holes in the heart, such as PFO and ASD. A growing area includes transcatheter mitral repair or replacement and transcatheter tricuspid valve repair and replacement.

Eli Lilly, Amylin ink $216M diabetes deal, begin new trial

Amylin Pharmaceuticals and Eli Lilly have entered, in principle, into a joint supply agreement for an exenatide once weekly pen device. The companies also have initiated a phase 1/2 clinical study to examine a new exenatide once weekly suspension formulation.

Circulation: More CPR compressions, less interruption lead to increased survival

Survival rates from out-of-hospital sudden cardiac arrest almost doubled when professional rescuers using cardiopulmonary resuscitation gave better chest compressions and minimized interruptions to them, according to research reported May 4 in Circulation.

NEJM: JUPITER sub-study finds Crestor cuts VTE risk 43%

Rosuvastatin (Crestor from AstraZeneca) significantly reduced the occurrence of symptomatic venous thromboembolism (VTE) in the atria of apparently healthy persons, according to a sub-study of the JUPITER trial published in the April 30 issue of the New England Journal of Medicine.

AIM: High co-pays keep chronically ill from starting meds

Patients newly diagnosed with hypertension, diabetes or high cholesterol are significantly more likely to delay initiating recommended drug treatment if they face higher co-payments for medications, according to a study published in the April 27 edition of the Archives of Internal Medicine.

Report: Global pharma market not recession-proof

The value of the global pharmaceutical market is expected to grow 2.5 to 3.5 percent on a constant-dollar basis in 2009--two percentage points lower than indicated in October 2008, as deterioration in the global economic environment continues to affect market demand, according to a report from IMS Health.

Cigna, Merck ink diabetes drug deal

Cigna has reached an agreement with Merck through which its customers can have access to increased discounts on Merck's oral anti-diabetes medications Januvia and Janumet--if Cigna provides evidence supporting medication use and glycemic control improvement in patients.

Good Samaritan Laws, Broad Access Help AEDs Save Lives

In 2008, the Sudden Cardiac Arrest Foundation honored Roman Matlaga with its first-ever People Saving People award for saving the life of a fellow basketball player who had collapsed during a game.After Matlaga administered CPR and one AED (automated external defibrillator) shock, the stricken man awoke and asked, "Did we win?" Although Matlaga is an emergency physician, he stressed that it doesn't take a doctor to save a life. "Any one of my teammates could have taken charge of the situation," he said.

Lilly posts 24% uptick in Q1

Eli Lilly has released its financial results for the first quarter of 2009, posting a 24 percent increase in net income of $1.31 billion, compared with $961.9 million from the same period last year.

Around the web

Ron Blankstein, MD, professor of radiology, Harvard Medical School, explains the use of artificial intelligence to detect heart disease in non-cardiac CT exams.

Eleven medical societies have signed on to a consensus statement aimed at standardizing imaging for suspected cardiovascular infections.

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