Structural Heart Disease

Structural heart diseases include any issues preventing normal cardiovascular function due to damage or alteration to the anatomical components of the heart. This is caused by aging, advanced atherosclerosis, calcification, tissue degeneration, congenital heart defects and heart failure. The most commonly treated areas are the heart valves, in particular the mitral and aortic valves. These can be replaced through open heart surgery or using cath lab-based transcatheter valves or repairs to eliminate regurgitation due to faulty valve leaflets. This includes transcatheter aortic valve replacement (TAVR). Other common procedures include left atrial appendage (LAA) occlusion and closing congenital holes in the heart, such as PFO and ASD. A growing area includes transcatheter mitral repair or replacement and transcatheter tricuspid valve repair and replacement.

Zoll books weak Q2, due to poor North American hospital sales

Zoll Medical, a manufacturer of resuscitation devices and software solutions, has reported net income of $1.78 million for the second quarter of 2009, compared with $5.65 million in net income for the same period last year.

NEJM: Novartis' Diovan fails to prevent a-fib recurrence

Treatment with Novartis' Diovan (valsartan) does not reduce the incidence of recurrent atrial fibrillation (AF), according to results of the GISSI-AF trial published in the April 16 issue of the New England Journal of Medicine.

Baxter sees strong Q1

Baxter International has reported 2009 first quarter net income of $516 million, an increase of 20 percent from the $429 million in net income it recorded in the first quarter of 2008.

Gilead completes purchase of CV Therapeutics

Biopharmaceutical firm Gilead Sciences has closed its acquisition of CV Therapeutics, a biopharmaceutical company focused on the development of small molecule drugs for the treatment of cardiovascular diseases.

Zoll Medical, FDA issue Class 1 defibrillator recall

Zoll Medical and FDA have notified healthcare professionals of a Class 1 recall of Zoll AED [automated external defibrillator] Plus Defibrillators distributed from May 2004 through Feb. 9, 2009. The recall was initiated because the device may fail to deliver a defibrillation shock, which could result in failure to resuscitate a patient during treatment of sudden cardiac arrest.

Express Scripts to buy WellPoint subsidiaries for $4.7B

Express Scripts, a pharmacy benefits management company, has signed a definitive agreement to acquire WellPoint's NextRx subsidiaries for $4.675 billion, which includes consideration for the value of a future tax benefit for Express Scripts based on the structure of the transaction.

Newer a-fib drugs gain popularity, despite lack of reimbursement

Cardiologists estimate they will prescribe Bayer/Johnson & Johnson's Xarelto to 36 percent of newly diagnosed atrial fibrillation patients, while primary care physicians estimate they will prescribe Xarelto to 29 percent, according to a new survey from healthcare and pharmaceutical research firm Decision Resources.

Pfizer restructures, retains some Wyeth execs

Pfizer has unveiled its planned leadership and organizational structure for research and commercial operations that will become effective when the Wyeth acquisition closes.

Around the web

Ron Blankstein, MD, professor of radiology, Harvard Medical School, explains the use of artificial intelligence to detect heart disease in non-cardiac CT exams.

Eleven medical societies have signed on to a consensus statement aimed at standardizing imaging for suspected cardiovascular infections.

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