Structural Heart Disease

Structural heart diseases include any issues preventing normal cardiovascular function due to damage or alteration to the anatomical components of the heart. This is caused by aging, advanced atherosclerosis, calcification, tissue degeneration, congenital heart defects and heart failure. The most commonly treated areas are the heart valves, in particular the mitral and aortic valves. These can be replaced through open heart surgery or using cath lab-based transcatheter valves or repairs to eliminate regurgitation due to faulty valve leaflets. This includes transcatheter aortic valve replacement (TAVR). Other common procedures include left atrial appendage (LAA) occlusion and closing congenital holes in the heart, such as PFO and ASD. A growing area includes transcatheter mitral repair or replacement and transcatheter tricuspid valve repair and replacement.

Medtronic income drops 38%, despite slight revenue increase

Medtronic has reported a decline in net income of financial results for its recent quarter, compared to a year ago.

More AEDs for Responders, Less Time with Refractory OHCA

Sudden cardiac arrest (SCA) survivor Chris Knight likes to say he died five times in one day and, in fact, he did. Knights heart stopped four more times after an initial SCA. Luckily for him, the city in Illinois where he was visiting equips all its police officers and first responders with automated external defibrillators (AEDs). His experience has made him into a crusader to have AEDs for all first responders in his part of the Texas Panhandle.

BMJ: Actos leads to less heart failure, death compared with Avandia

Among older patients with diabetes, pioglitazone (Actos) is associated with a significantly lower risk of heart failure and death than is rosiglitazone (Avandia), according to a retrospective cohort study published Aug. 18 in the British Medical Journal.

JACC: ACE inhibitors may independently predict worse outcomes after CABG

Pre-operative therapy with angiotensin-converting enzyme (ACE) inhibitors is associated with an increased risk of mortality, use of inotropic support, post-operative renal dysfunction and new onset of post-operative atrial fibrillation, based on research reported online Aug. 12 in the Journal of the American College of Cardiology.

AIM: ARBs do not improve renal outcomes in patients with heart disease

In adults with vascular disease but without macroalbuminuria, the effects of telmisartan on major renal outcomes were similar to those of placebo, according to an analysis of the TRANSCEND trial published July 7 in the Annals of Internal Medicine.

Circulation: Doctor-pharmacist partnership reduces heart failure hospitalization

Thinking "outside the medicine cabinet" is paying off in Australia, where a doctor-pharmacist partnership is reducing hospitalizations for heart failure, researchers reported Aug. 18 in Circulation: Heart Failure.

Merck, Schering-Plough settle Vytorin, Zetia suits for $41.5M

Merck, Schering-Plough and the companies' cholesterol joint venture, Merck/Schering-Plough Pharmaceuticals (MSP), have entered into agreements to resolve, for a total fixed amount of $41.5 million, civil class action litigation currently pending against the companies relating to the purchase or use of Vytorin (ezetimibe/simvastatin) and Zetia (ezetimibe).

Lilly reveals $22M in physician payments in Q1

Eli Lilly has launched an online registry detailing recent payments that it has made to physicians and other healthcare professionals for the first quarter of 2009, totaling $22 million. The company said it will update the registry quarterly going forward.

Around the web

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