Structural Heart Disease

Structural heart diseases include any issues preventing normal cardiovascular function due to damage or alteration to the anatomical components of the heart. This is caused by aging, advanced atherosclerosis, calcification, tissue degeneration, congenital heart defects and heart failure. The most commonly treated areas are the heart valves, in particular the mitral and aortic valves. These can be replaced through open heart surgery or using cath lab-based transcatheter valves or repairs to eliminate regurgitation due to faulty valve leaflets. This includes transcatheter aortic valve replacement (TAVR). Other common procedures include left atrial appendage (LAA) occlusion and closing congenital holes in the heart, such as PFO and ASD. A growing area includes transcatheter mitral repair or replacement and transcatheter tricuspid valve repair and replacement.

Patient death halts Aastrom heart failure stem cell trial

Aastrom Biosciences, a developer of autologous adult stem cell treatments for cardiovascular diseases, has temporarily suspended enrollment and patient treatment in its U.S. Phase II IMPACT-DCM clinical trial, following a report that a trial participant who received the recommended treatment died at home after being released from the hospital.

AstraZeneca to disclose compensation to U.S. doctors

AstraZeneca has announced that it plans to divulge compensation to healthcare professionals who speak on behalf of its company and products in the U.S. starting in 2010.

Gilead shuffles CV execs as part of CV Therapeutics integration

Biopharmaceutical firm Gilead Sciences, as part of the ongoing integration of CV Therapeutics, has announced changes to its cardiovascular research and development organization leadership.

Amgen collects $50M in heart failure drug deal with Cytokinetics

Amgen has exercised its option to obtain an exclusive license, globally (excluding Japan), to Cytokinetics' cardiac contractility program. The license includes CK-1827452, a new cardiac myosin activator being developed for the treatment of heart failure.

Ranbaxy CEO, chair voted out

Daiichi Sankyo and Ranbaxy Laboratories announced that Malvinder Mohan Singh has stepped down from the positions of chairman, CEO and managing director of Ranbaxy with immediate effect.

Pfizer income slips in Q1; Lipitor sales affected by generics

Pfizer has reported a slight drop in net income in its financial results for the 2009 first quarter, which ended March 29, impacted by decreased revenues from the pending Wyeth acquisition as well as strong pressure from generic competitors for Lipitor.

KLAS: Providers demand greater integration from pharmacy software vendors

As healthcare providers move to adopt e-prescribing and drive greater patient safety, the need for better integration between core clinical systems and pharmacy automation software continues to grow. How well pharmacy software vendors deliver on that integration is having a significant impact on provider adoption and satisfaction, according to a report from market research firm KLAS.

Pharmaceutical Market is not Recession-Proof

An updated forecast of global pharma sales comes up nearly a billion dollars shy of the forecast from October, suggesting that the pharmaceutical market is indeed not recession-proof, according to a report from IMS Health . Innovation in drug therapy, however, continues to forge ahead and its interesting to follow the pharma industry as it adapts to tough economic times.Two combo pills for hypertension have received the nod from the FDA to move forward. Daiichi Sankyos Azor, which combines two medications, and Novartis Exforge HCT, a combination of three meds. Drug compliance is problematic when cardiac patients feel overwhelmed with the number of pills they must take daily. The movement to combine several medications into one pill seems to be on the right track.

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