Acute Coronary Syndromes

Acute coronary syndrome (ACS) is most commonly caused by a heart attack (myocardial infarction) where blood flow to the heart is suddenly blocked. This is usually caused by a blood clot from a ruptured coronary artery atherosclerotic plaque. Other causes include spontaneous coronary artery dissection (SCAD), which most commonly occurs in women. ACS is usually treated in a cath lab with angioplasty and the placement of a stent to prop the vessel open.

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Study shows race doesn't affect PCI outcomes—but does influence treatment decisions

A new JAMA: Cardiology study comparing the outcomes of percutaneous coronary intervention (PCI) in black and white patients showed no difference in one-year mortality rates, but it did shed light on other racial gaps in the cardiovascular treatment process.

Cardiovascular disease spiked in year after New Zealand earthquakes

Middle-aged and older residents in the hardest-hit areas suffered 25 percent more cardiovascular-related deaths in the year after the Canterbury earthquakes when compared to neighbors in lesser-impacted areas.

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Exercise can’t prevent cognitive decline in patients with coronary heart disease

Patients with stable coronary heart disease (CHD)—despite being considered “fit” and participating in phase III cardiac rehabilitation—demonstrated worse cognitive function when compared to healthy, age-matched individuals in a single-center study published in PLOS One.

Stopping aspirin therapy associated with 37% increased risk of cardiovascular events

In patients with a previous history of stroke or heart attack, discontinuation was associated with a 46 percent increased risk—translating to one additional cardiovascular event per year per 36 patients who stopped taking aspirin.

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Cardiac adrenaline boost from e-cigarettes tied to nicotine

Nicotine in electronic cigarettes boosts the cardiac adrenaline levels of users, which could put them at increased risk for heart disease, according to a new study in the Journal of the American Heart Association.

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Adherence to medications post-MI is below 50%; beta-blockers offer little incremental benefit

Based on clinical guidelines, three therapies are often prescribed together following acute MI: angiotensin-converting enzyme (ACE) inhibitors/angiotensin II receptor blockers (ARBs), beta-blockers and statins. But are they equally important?

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Researchers confirm link between retinal vein occlusion, heart attack

In a large, retrospective study of the Taiwan population, researchers found individuals with retinal vein occlusion (RVO) demonstrated an adjusted risk increase of 21 percent for suffering a heart attack.

G3 Pharmaceuticals to Pursue a Novel Class of Cardiovascular Pharmaceuticals

LEXINGTON, Mass., Sept. 14, 2017 — G3 Pharmaceuticals, a newly formed biopharmaceutical company located in Lexington, MA, today announced the start of its research and development program to pursue novel galectin-3 inhibitors.   Galectin-3 is a protein that is responsible for fibrosis forming in the heart and kidney, which impairs organ function, leading to heart failure, atrial fibrillation, and impaired kidney function.

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