Clinical Research

Cian McCarthy, MD, cardiovascular fellow, Massachusetts General Hospital, and a member of the National Cardiovascular Data Registry (NCDR) Chest Pain-MI registry steering committee, explains a study of the NCDR data showing only 33% of hospitals are using high-sensitivity troponin. However, he expects that to rise because of high sensitivity troponin (hs-cTn) being included in recent guidelines as a front-line test.

VIDEO: High sensitivity cardiac troponin use based on the NCDR Chest Pain-MI Registry 

Cian McCarthy, MD, Massachusetts General Hospital, and a member of the National Cardiovascular Data Registry (NCDR) Chest Pain-MI registry steering committee, explains a study of the NCDR data showing only 33% of hospitals are using high-sensitivity troponin.

New data from the Phase 3 RAPID clinical trial of etripamil, an investigational calcium channel blocker nasal spray, showed positive results in converting paroxysmal supraventricular tachycardia (PSVT) to normal sinus rhythm in the at-home setting. The presentation was featured during a late-breaking clinical trials session at the American Heart Association (AHA) 2022 Scientific Sessions. #AHA22

Etripamil nasal spray meets primary endpoint of terminating paroxysmal supraventricular tachycardia 

The drug allows patients to take control over their condition with self administration and the therapy and may help lower healthcare costs and resource utilization by keeping these patients out of emergency rooms. 

Jason Andrade, MD, FRCPC, FHRS, director of electrophysiology, Vancouver General Hospital, clinical associate professor, University of British Columbia, and principal investigator for the PROGRESSIVE AF trial, explains how cryoablation can be used as a front-line treatment for atrial fibrillation (AFib). He presented this late-breaking trial at the American Heart Association (AHA) 2022 meeting, which showed the therapy can be used instead of trying drug therapy first. #AHA22 #EPeeps

VIDEO: Cryoablation can be used as frontline therapy before drugs: PROGRESSIVE AF trial

Jason Andrade, MD, director of electrophysiology, Vancouver General Hospital, and principal investigator of the PROGRESSIVE AF trial, explains how cryoablation can be used as a frontline treatment for atrial fibrillation (AFib) before drugs in this AHA late-breaker. 

The Medtronic Symplicity Spyral Renal Denervation system uses a catheter that curls in the renal artery to place radiofrequency electrodes against the vessel wall to ablate the nerves that control vasodilation, so the artery can be propped in the fully open position.

SPYRAL HTN-ON MED renal denervation study did not meet primary endpoint

The SPYRAL HTN-ON MED renal denervation trial failed to show that renal denervation was superior to sham control at improving ambulatory blood pressure (ABPM), but that might have been due to patient lifestyle changes during COVID-19.

Pulmonary hypertension (PAH) is usually treated with medication, but the more a patient has to pay for medications, the less likely they are to take them and become noncompliant. This was the finding of a new study showing how copayments may be a barrier to patients taking prostanoids and combination therapy for PAH.

Higher copayments lowered adherence for pulmonary artery hypertension medications 

The more a patient has to pay for medications, the less likely they are to take them. This was the finding of a new study showing how copayments may be a barrier to drugs to treat pulmonary arterial hypertension.

Image from the American Heart Association (AHA) annual scientific sessions where a large amount of late-breaking cardiology science is presented. #AHA #AHA22 #AHA2022

Links to the American Heart Association 2022 late-breaking studies

The American Heart Association 2022 Scientific Sessions included 35 late-breaking studies and 39 featured science sessions presented at the meeting in Chicago, Nov. 5-7. Here is the list of all these studies with links to more information on the data.

Medtronic’s Arctic Front cryoballoon catheters

Treating AFib early with cryoablation reduces risk of disease progression, repeat hospitalization

“The evidence shows increasingly that it’s time to rethink how we approach the treatment of AFib,” one researcher said.

James Udelson, MD, from Tufts and an investiogator in the PRECISE trial, explains how FFR-CT combined with coronary CT outperformed the standard of care in patients with stable chest pain, or low-risk patients with suspected coronary involvement.

VIDEO: PRECISE trial shows cardiac CT with FFR-CT significantly improves patient outcomes

James Udelson, MD, an investigator involved with the PRECISE trial, explained how patient outcomes were improved by 70% from the current standard of care.

Around the web

Ron Blankstein, MD, professor of radiology, Harvard Medical School, explains the use of artificial intelligence to detect heart disease in non-cardiac CT exams.

Eleven medical societies have signed on to a consensus statement aimed at standardizing imaging for suspected cardiovascular infections.

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