Heart Failure

Heart failure occurs when the heart cannot pump as much blood as the body requires. This ineffective pumping can lead to enlargement of the heart as the myocardium works harder pump the same amount of blood. Heart failure may be caused by defects in the myocardium, such as an a heart attack infarct, or due to structural issues such as severe heart valve regurgitation. Heart failure can be divided into HF with preserved ejection fraction (HFpEF), and HF with reduced ejection fraction (HFrEF). The disease is further divided into four New York Heart Association (NYHA) classes. Stage IV heart failure is when the heart is completely failing and requires a heart transplant or hemodynamic support from a left ventricular assist device (LVAD).

Loneliness and isolation lead to a 30% increased risk in heart disease, stroke

A study published by Heart found that loneliness and social isolation are linked to a 30 percent increased risk of having a stroke or developing coronary artery disease, the two leading causes of death for men and women.

Experimental heart failure medication meets primary endpoint in phase 2b trial

Vericel Corp. announced on March 10 that its experimental drug to treat advanced heart failure due to ischemic dilated cardiomyopathy met the primary endpoint in a phase 2b clinical trial.

Self-care does not improve mortality in chronic heart failure patients

Patients with chronic heart failure and high scores on a global self-care scale had similar rates of long-term, all-cause mortality compared with those with low scores, according to a secondary analysis from two observational prospective studies. 

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Recovery Time: Despite Proven Benefits, Cardiac Rehabilitation Remains Underused

AACVPR is working to redefine how cardiac rehabilitation is referred, provided and reimbursed.

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Model finds the CardioMEMS device is cost-effective for heart failure patients

A model-based study found that patients with chronic heart failure who used the CardioMEMS device had reductions in hospitalizations and increases in quality-adjusted life-years (QALYs) and costs.

Novartis agrees to pay-for-performance agreements with insurers to cover heart failure drug

Novartis has entered into a pay-for-performance agreement with Cigna to cover sacubitril/valsartan (Entresto), a twice-daily oral medication to treat patients with heart failure and reduced ejection fraction. Aetna also signed a value-based agreement with Novartis based on the drug having similar results as shown in clinical trials, according to a Reuters report.

Exercising and dieting improves exercise capacity but not quality of life in older, obese heart failure patients

After a 20-week regimen that included an improved diet and/or an increased exercise regiment, obese, older adults with heart failure had an increase in exercise capacity, according to a randomized trial conducted at an urban academic medical center. However, the regimen did not have a significant effect on quality of life.

Age-adjusted heart failure-related deaths increase from 2012 to 2014

After declining for more than a decade, the age-adjusted rate for heart failure-related deaths increased from 2012 to 2014, according to a recent data brief from the National Center for Health Statistics.

Around the web

Ron Blankstein, MD, professor of radiology, Harvard Medical School, explains the use of artificial intelligence to detect heart disease in non-cardiac CT exams.

Eleven medical societies have signed on to a consensus statement aimed at standardizing imaging for suspected cardiovascular infections.