Heart Failure

Heart failure occurs when the heart cannot pump as much blood as the body requires. This ineffective pumping can lead to enlargement of the heart as the myocardium works harder pump the same amount of blood. Heart failure may be caused by defects in the myocardium, such as an a heart attack infarct, or due to structural issues such as severe heart valve regurgitation. Heart failure can be divided into HF with preserved ejection fraction (HFpEF), and HF with reduced ejection fraction (HFrEF). The disease is further divided into four New York Heart Association (NYHA) classes. Stage IV heart failure is when the heart is completely failing and requires a heart transplant or hemodynamic support from a left ventricular assist device (LVAD).

Trial offers 'reassuring' evidence of low Sitagliptin complications

An analysis of a randomized clinical trial found patients with cardiovascular disease and type 2 diabetes who received sitagliptin had similar rates of heart failure or other cardiovascular complications compared with a placebo group.

Clinical risk score helps predict stroke and death in heart failure patients

A clinical risk score helped predict the risk of ischemic stroke, thromboembolism and death in patients with heart failure, according to an analysis of three nationwide registries in Denmark. However, the researchers noted the predictive accuracy was modest.

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Nearly 90% of patients with heart failure are not referred to cardiac rehabilitation

Only 10 percent of patients with heart failure were referred to cardiac rehabilitation after hospital discharge between 2005 and 2014, according to a database analysis. Although the referral rates were higher in recent years, the researchers noted that they expected more people to be told to attend cardiac rehabilitation sessions.

Symptoms persist in patients hospitalized for heart failure

A large percentage of patients hospitalized for heart failure at Yale-New Haven hospital had symptoms such as anxiety and pain that are typically not associated with the condition, according to a prospective study. The researchers also found that patients often did not have improvements in symptom severity after getting discharged.

Moderate levels of physical activity may reduce heart failure risk in men

After a mean follow-up of 13 years, Swedish men who had moderate levels of physical activity had a lower risk of heart failure compared with those who had high or low activity levels, according to a population-based cohort study.

FDA warns of serious adverse events with LVADs

The FDA warned of serious adverse events associated with certain left ventricular assist devices (LVADs), which are implanted in patients with advanced heart failure.

Social media sites growing in popularity for LVAD patients and caregivers

Since former Vice President Dick Cheney had a left ventricular assist device (LVAD) implanted in 2012, general interest in the devices have increased and social media sites have included more information on them.

Investigational cardiac implantable device shows no improvement over placebo

Bellerophon Therapeutics announced on July 27 that top-line results from a clinical trial found its investigational cardiac implantable device did not improve outcomes compared with placebo.

Around the web

Ron Blankstein, MD, professor of radiology, Harvard Medical School, explains the use of artificial intelligence to detect heart disease in non-cardiac CT exams.

Eleven medical societies have signed on to a consensus statement aimed at standardizing imaging for suspected cardiovascular infections.