Heart Failure

Heart failure occurs when the heart cannot pump as much blood as the body requires. This ineffective pumping can lead to enlargement of the heart as the myocardium works harder pump the same amount of blood. Heart failure may be caused by defects in the myocardium, such as an a heart attack infarct, or due to structural issues such as severe heart valve regurgitation. Heart failure can be divided into HF with preserved ejection fraction (HFpEF), and HF with reduced ejection fraction (HFrEF). The disease is further divided into four New York Heart Association (NYHA) classes. Stage IV heart failure is when the heart is completely failing and requires a heart transplant or hemodynamic support from a left ventricular assist device (LVAD).

Aranesp misses mark in HF trial

The RED-HF trial failed to meet its primary endpoint of reducing the composite endpoint of time to death from any cause or first hospital admission for worsening heart failure, Amgen announced.

Depression, renal dysfunction increase risk of VAD infection

A prospective, multicenter study of 145 patients who received ventricular assist devices (VAD) found that infection remains a persistent problem, and that depression and elevated creatinine levels are independent predictors of VAD infection.

Experts offer guidelines on circulatory support devices

An international and multidisciplinary team of experts has developed guidelines to assist physicians who treat patients with mechanical circulatory support devices (MCSDs). The executive summary with recommendations was published in the February issue of the Journal of Heart and Lung Transplantation.

HF: Can observation units reduce readmissions?

There is consensus that reducing hospital admissions and readmissions for heart failure (HF) is critical, but not on the best path to follow to reach those goals.

Pediatric survival of in-hospital cardiac arrest improving, but remains low

A study of in-hospital cardiac arrest survival rates in children found that hospitals participating in the Get With the Guidelines-Resuscitation (GWTG-Resuscitation) program have improved overall survival rates threefold over the past 10 years, without worsened neurological outcome among survivors. The overall survival rate remains under 50 percent, however. The study was published online Dec. 18 in Circulation: Cardiovascular Quality and Outcomes.

Readmissions & reassessing PCI practices

Earlier this month, analysts at Fitch Ratings shared information that informed their outlook on the fiscal health of nonprofit hospitals and health systems in 2013. They foresaw a stable year, barring deep cuts in Medicare and Medicaid.

More hospitalizations: Secret to improving HF mortality?

In what researchers acknowledge is a counterintuitive finding, a study of real-world outcomes in multidisciplinary heart failure (HF) clinics found a higher rate of hospitalizations in patients seen at clinics compared with those who were not.

Japan clears HeartMate II as bridge therapy

Japan’s Ministry of Health, Labor and Welfare has approved HeartMate II as a bridge-to-transplantation therapy for patients suffering from advanced heart failure.

Around the web

Ron Blankstein, MD, professor of radiology, Harvard Medical School, explains the use of artificial intelligence to detect heart disease in non-cardiac CT exams.

Eleven medical societies have signed on to a consensus statement aimed at standardizing imaging for suspected cardiovascular infections.

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