SAN FRANCISCO, May 3, 2018 /PRNewswire/ — Eidos Therapeutics, Inc., a clinical stage biopharmaceutical company developing a novel oral therapy to treat transthyretin (TTR) amyloidosis (ATTR), today announced dosing of the first patient in the Phase 2 clinical trial of AG10 in patients with ATTR cardiomyopathy.

High-intensity statin therapy for peripheral artery disease (PAD) patients reduces the risk of lower-extremity amputations by one-third and the risk of mortality by 26 percent, a new study found. However, the lipid-lowering drugs remain underutilized in the PAD population despite their guideline-recommended use.

Three leading cardiology societies released a consensus statement on Dec. 10 regarding criteria institutions and operators should follow for left atrial appendage occlusion.

If patients who experience pulmonary embolism take warfarin for two years, their risk of blood clots and major bleeding are significantly reduced. However, if they stop treatment, the benefits do not last, according to a French multicenter, randomized, double-blind study published this month in JAMA.

Bristol-Myers Squibb Company (NYSE:BMY) and Pfizer Inc. (NYSE:PFE) today announced that the European Commission has approved Eliquis for the treatment of DVT and PE, and the prevention of recurrent DVT and PE in adults. The European Commission approval applies to all European Union (EU) member states as well as Iceland and Norway. Eliquis is also approved in the EU for the prevention of venous thromboembolism (VTE) in adults who have undergone elective total hip or knee replacement surgery, and for the prevention of stroke and systemic embolism in adult patients with nonvalvular atrial fibrillation (NVAF) with one or more risk factors.

Boehringer Ingelheim today announces that Pradaxa (dabigatran etexilate) has been approved by the European Commission for the treatment and prevention of recurrence of deep vein thrombosis (DVT) and pulmonary embolism (PE). The U.S. Food and Drug Administration (FDA) approved Pradaxa for DVT and PE patients earlier this year. DVT and PE can be very dangerous; almost one in three PE patients dies within three months and four out of 10 patients suffer a repeat blood clot within 10 years of the first.

The U.K.’s National Institute for Health and Care Excellence (NICE) has recommended the anticoagulant rivaroxaban as a possible treatment for adults with pulmonary embolism and to prevent recurrent deep vein thrombosis or pulmonary embolism.

Patients with paroxysmal atrial fibrillation (AF) were less likely to receive guideline recommended anticoagulation therapy compared with persistent AF patients. The analysis presented May 8 at the Heart Rhythm Society scientific sessions in Denver included registry data on more than 62,000 patients.