TAVR

Transcatheter aortic valve replacement (TAVR) is a key structural heart procedure that has rapidly expanded in the decade since it was first FDA cleared. TAVR has come a paradigm shift in how many aortic stenosis patients are treated, now making up more than 50% of U.S. aortic valve replacements. It is less invasive than open heart surgery and recovery times are greatly reduced. TAVR can also be used in patients who otherwise are too high risk to undergo surgery. TAVR is referred to as transcatheter aortic valve implantation (TAVI) in many placed outside of the U.S. TAVR inspired the growing areas of transcatheter mitral repair or replacement and transcatheter tricuspid valve repair and replacement.

healthcare business deal

Edwards continues valve-focused M&A streak by acquiring promising TAVR startup

The move makes it crystal clear that Edwards remains focused on pursuing advanced TAVR technologies. The company just acquired JenaValve, another company dedicated to developing new AR treatments, back in July.

The J-Valve manufactured by JC Medical, a Genesis MedTech company, includes a self-expanding nitinol frame, bovine pericardial leaflets and three anchor rings designed to assist operators with alignment. Its delivery system was built with transfemoral access in mind, and JC Medical plans to offer the valve in five different sizes.

New TAVR valve for native aortic regurgitation linked to positive 30-day outcomes

The J Valve from JC Medical was linked to positive outcomes and “excellent” hemodynamic data after 30 days in an early feasibility study published in JACC: Cardiovascular Interventions. Researchers noted that the valve showed potential in patients with large aortic annuli, which represents an "unmet critical need" at this stage. 

Boston Scientific's Sentinel Cerebral Protection System during a TAVR procedure

Cerebral protection during TAVR linked to lower risk of major stroke, other key benefits

Using a cerebral protection device during TAVR was associated with lower readmission rates, shorter hospital stays—and, yes, a lower risk of patients suffering a major stroke. A team of specialists with Cleveland Clinic shared their new findings in the Journal of the American Heart Association.

Medtronic CoreValve TAVR first-generation transcatheter heart valve

First-generation Medtronic TAVR valves linked to strong outcomes after 12 years

Researchers tracked the long-term safety, effectiveness and durability of first-generation CoreValve devices in nearly 900 patients.

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Stroke after TAVR in AFib patients: Key risk factors cardiologists should know

Reviewing a patient's medical history can help care teams select the optimal post-TAVR oral anticoagulation strategy.

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Edwards Lifesciences agrees to acquire JenaValve, Endotronix for $1.2B

While JenaValve is known for its Trilogy Heart Valve System, a device designed specifically to treat aortic regurgitation, Endotronix specializes in developing heart failure technologies. The news comes after Edwards sold its critical care business for $4.2 billion in June, saying it would double down on its structural heart portfolio. 

A TAVR procedure being performed at Northwestern Medicine in Chicago. These structural heart procedures require a team approach.

Prosthesis-patient mismatch after TAVR makes minimal impact on long-term outcomes

Researchers tracked SWEDEHEART data from more than 8,000 TAVR patients treated from 2008 to 2022. Overall, they said, PPM after TAVR was rare, and its impact on outcomes was "negligible."

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Get SMART: Cardiologist says new TAVR data changed his perspective on treating women with symptomatic severe AS

Sponsored by Medtronic

Physicians and researchers complete thousands of clinical trials each year, but some findings prove far more significant than others. For cardiologist Dharmesh Patel, MD, the results of the SMART trial have changed the way he’s managing and recommending treatment for women with symptomatic severe aortic stenosis.

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