Structural Heart Disease

Structural heart diseases include any issues preventing normal cardiovascular function due to damage or alteration to the anatomical components of the heart. This is caused by aging, advanced atherosclerosis, calcification, tissue degeneration, congenital heart defects and heart failure. The most commonly treated areas are the heart valves, in particular the mitral and aortic valves. These can be replaced through open heart surgery or using cath lab-based transcatheter valves or repairs to eliminate regurgitation due to faulty valve leaflets. This includes transcatheter aortic valve replacement (TAVR). Other common procedures include left atrial appendage (LAA) occlusion and closing congenital holes in the heart, such as PFO and ASD. A growing area includes transcatheter mitral repair or replacement and transcatheter tricuspid valve repair and replacement.

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Guidelines: Good, bad & unreimbursed

Various guidelines appear to be under the magnifying glass these days, with dissenters challenging the need to follow recommendations. This may be part of a healthy debate. But how about instances where cardiologists are penalized for following evidence-based recommendations?

Vorapaxar gets 10-1 thumbs up from FDA panel

The FDA’s Cardiovascular and Renal Drugs Advisory Committee voted 10-1 in favor of approval for the antiplatelet vorapaxar to reduce atherothrombotic events in patients with a history of MI.

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Cholesterol guidelines: Try mixing old with new

A team of cardiologists at the Cleveland Clinic recommended a hybrid approach using previous and new guidelines for treating patients with high cholesterol levels who are at risk of atherosclerotic cardiovascular disease. They praised the simplicity of recently released guidelines but faulted their reliance on randomized clinical trial data and an untested risk calculator.

Evidence doesn't support higher SBP goal, panel members argue

Although the Eighth Joint National Committee recently recommended raising the systolic blood pressure (SBP) goal from 140 mm Hg to 150 in people 60 years of age and older without diabetes mellitus or chronic kidney disease, five members of the panel disagreed in a viewpoint published online Jan. 14 in Annals of Internal Medicine. They argued that there was not sufficient evidence to increase the target SBP.

DOJ subpoenas Aegerion over Juxtapid

Aegerion Pharmaceuticals confirmed that it is under a federal magnifying glass again. The company disclosed in a financial statement that it was subpoenaed by the Department of Justice (DOJ) over its cholesterol drug, lomitapide.

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Q&A: ACC/AHA’s Provocative Prevention Guidelines

The release of four prevention guidelines from the American College of Cardiology (ACC) and the American Heart Association (AHA) raised eyebrows, particularly over the use of a new cardiovascular risk calculator and the abandonment of number targets for cholesterol management. 

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Choosing TAVR

With transcatheter aortic valve replacement (TAVR), proper patient selection plays a key role in successful outcomes. 

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PTSD & Heart Disease: A Vicious Cycle

For men and women living with post-traumatic stress disorder (PTSD), their bodies may be as profoundly affected as their minds.

Around the web

Several key trends were evident at the Radiological Society of North America 2024 meeting, including new CT and MR technology and evolving adoption of artificial intelligence.

Ron Blankstein, MD, professor of radiology, Harvard Medical School, explains the use of artificial intelligence to detect heart disease in non-cardiac CT exams.