Structural Heart Disease

Structural heart diseases include any issues preventing normal cardiovascular function due to damage or alteration to the anatomical components of the heart. This is caused by aging, advanced atherosclerosis, calcification, tissue degeneration, congenital heart defects and heart failure. The most commonly treated areas are the heart valves, in particular the mitral and aortic valves. These can be replaced through open heart surgery or using cath lab-based transcatheter valves or repairs to eliminate regurgitation due to faulty valve leaflets. This includes transcatheter aortic valve replacement (TAVR). Other common procedures include left atrial appendage (LAA) occlusion and closing congenital holes in the heart, such as PFO and ASD. A growing area includes transcatheter mitral repair or replacement and transcatheter tricuspid valve repair and replacement.

Trial to assess once-daily polypill to decrease CV events

Researchers at the Imperial College in London are launching an international clinical trial that will test the waters of a once-daily polypill containing aspirin, a statin and two blood pressure lowering medications to reduce cardiovascular (CV) events.

Pfizer to cut 6,000 jobs, close another eight plants

Pfizer today announced plans to shutter eight manufacturing plants and to reduce the workforce by 6,000 at six other sites.

HRS: Vernakalant trumps amiodarone in sinus rhythm conversion

DenverThe intravenous pharmacologic agent vernakalant fared better than amiodarone to make the conversion of recent onset AF to sinus rhythm in patients suffering from atrial fibrillation (AF), according to a late-breaking clinical trial presented at the Heart Rhythm Society (HRS) scientific sessions last Friday.

JAMA: Improving risk factor treatment lowers CHD death rate

From 1994 to 2005 in Ontario, Canada, there was a 35 percent decrease in the rate of deaths from coronary heart disease (CHD), with about half of this reduction associated with physiological improvements in traditional CHD risk factors such as total cholesterol levels and systolic blood pressure, according to a study in the May 12 issue of the Journal of the American Medical Association.

ElexoPharm, Merck partner to develop CVD treatment

ElexoPharm GmbH, a biotechnology company, has partnered with Merck to develop and market novel aldosterone synthase agents to better treat cardiovascular disease.

Study: Novel compound could lead to anti-diabetes drugs

Researchers have developed a compound that acts to keep insulin in the body longer, thereby potentially paving the way for a new class of drugs for treating diabetes, according to a study published in the May issue of PLoS ONE.

Video: HRS President Page touts sudden cardiac arrest campaign

Heart Rhythm Society (HRS) President Richard L. Page, MD, who is also chair of the department of medicine at the University of Wisconsin School of Medicine and Public Health, speaks to Cardiovascular Business News about its sudden cardiac arrest awareness Apples & Oranges campaign.

When to shock hearts during mechanical chest compressions

Pauses for shock delivery in chest compressions are detrimental to the success of resuscitation and may be eliminated with the use of mechanical chest compressors. However, it is important to deliver the shock at just the most optimal time. Researchers found defibrillation efficacy is maximal when electrical shock is delivered in the upstroke phase of mechanical chest compression. The study was published in the June issue of Resuscitation.

Around the web

Ron Blankstein, MD, professor of radiology, Harvard Medical School, explains the use of artificial intelligence to detect heart disease in non-cardiac CT exams.

Eleven medical societies have signed on to a consensus statement aimed at standardizing imaging for suspected cardiovascular infections.

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