Heart Failure

Heart failure occurs when the heart cannot pump as much blood as the body requires. This ineffective pumping can lead to enlargement of the heart as the myocardium works harder pump the same amount of blood. Heart failure may be caused by defects in the myocardium, such as an a heart attack infarct, or due to structural issues such as severe heart valve regurgitation. Heart failure can be divided into HF with preserved ejection fraction (HFpEF), and HF with reduced ejection fraction (HFrEF). The disease is further divided into four New York Heart Association (NYHA) classes. Stage IV heart failure is when the heart is completely failing and requires a heart transplant or hemodynamic support from a left ventricular assist device (LVAD).

Study: Women with HF at lower risk of death than men

Women with heart failure (HF) have a lower risk of death than their male counterparts, regardless of ejection fraction (EF), according to a meta-analysis published March 8 in the European Journal of Heart Failure. The analysis, based on data on nearly 42,000 patients, is said to be the largest assessment yet of gender and mortality risk in HF.

JAHA: Multiple evidence-based therapies may be best recipe for HF patients

Employing guideline-recommended therapies in heart failure (HF) patients extends survival; however, benefits seem to plateau after any four to five therapies are used, according to results of a study published in the Feb. 22 issue of the online, open-access Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease (JAHA).

JACC: Baseline anemia doesn't predict death in HF, renal dysfunction outpatients

Baseline anemia was not an independent predictor of all-cause mortality in outpatients with heart failure (HF) and severe renal dysfunction or advanced heart disease in a study published Jan. 24 in the Journal of the American College of Cardiology.

FDA gives go-ahead to ST2 biomarker assay

Critical Diagnostics' Presage ST2 Assay, a cardiac biomarker assay that can be used in the prognosis of patients with chronic heart failure, was cleared by the FDA Dec. 15.

FDA agrees to review apixaban for AF patients

The FDA accepted for review a new drug application (NDA) for the anticoagulant apixaban (Eliquis, Bristol-Myers Squibb/Pfizer) and assigned a priority review designation, the pharmaceutical companies announced Nov. 29. The goal date for issuing a decision is March 28, 2012.

JAMA: Surgery improves survival for infective endocarditis patients with HF

Patients with infective endocarditis complicated by heart failure (HF) who undergo valvular surgery had lower in-hospital and one-year mortality rates, researchers report in the Nov. 23 issue of the Journal of the American Medical Association. Yet less than two-thirds of patients with HF underwent surgery, the authors found.

AHA: Pharmacist intervention ups prescriptions, but not HF outcomes

ORLANDO, Fla.--A trial of a pharmacist-led intervention in primary care that aimed to optimize preventive heart failure (HF) treatment modestly improved the prescription of lifesaving drugs but did not improve clinical outcomes, according to the Post-MI FREE late-breaking clinical trial presented Nov. 14 at the 2011 American Heart Associations scientific sessions.

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AHA video: Remote program as effective as in-person for obesity

ORLANDO, Fla.A weight loss program delivered by health coaches over the phone with website and email support, but no in-person contact was as effective as one delivered in person, the studys lead researcher Lawrence J. Appel, MD, MPH, explained to Cardiovascular Business, who also spoke to the growing trend within U.S. healthcare system.

Around the web

Ron Blankstein, MD, professor of radiology, Harvard Medical School, explains the use of artificial intelligence to detect heart disease in non-cardiac CT exams.

Eleven medical societies have signed on to a consensus statement aimed at standardizing imaging for suspected cardiovascular infections.

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