Heart Failure

Heart failure occurs when the heart cannot pump as much blood as the body requires. This ineffective pumping can lead to enlargement of the heart as the myocardium works harder pump the same amount of blood. Heart failure may be caused by defects in the myocardium, such as an a heart attack infarct, or due to structural issues such as severe heart valve regurgitation. Heart failure can be divided into HF with preserved ejection fraction (HFpEF), and HF with reduced ejection fraction (HFrEF). The disease is further divided into four New York Heart Association (NYHA) classes. Stage IV heart failure is when the heart is completely failing and requires a heart transplant or hemodynamic support from a left ventricular assist device (LVAD).

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JACC editors: Clinical research culture in US lags behind other nations

Two editors of JACC: Heart Failure detailed how the United States has fallen behind other countries in site-based clinical research and offered suggestions on how to reinvigorate the research culture in America.

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Adults born preterm show impaired left ventricular function during exercise

The hearts of adults who are born prematurely don’t function as well during exercise, possibly explaining why they’re more at risk for early heart failure, according to a study published March 19 in the Journal of the American College of Cardiology.

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Canagliflozin linked to fewer deaths, heart failure hospitalizations for type 2 diabetics

Canagliflozin reduced the risk of death or hospitalization for heart failure by 22 percent among patients with type 2 diabetes and a high risk of cardiovascular disease, according to results of the CANVAS trial presented March 11 at the American College of Cardiology’s scientific session and published simultaneously in Circulation.

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Mortality risk model combines EHR data, language processing to account for frailty

Applying natural language learning and deep neural networks to mortality risk models could help predict cardiovascular outcomes with more accuracy than modern support vector machines, researchers said at the 67th annual American College of Cardiology conference in Orlando.

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Caregiver burden highest immediately after LVAD placement

A study of 50 sets of patients and caregivers suggests the first month after left ventricular assist device (LVAD) implantation is when the patient’s quality of life improves the most—but also when the caregiver is under the most stress.

Boehringer Ingelheim and Lilly expand heart failure program for Jardiance® with new exercise capacity trials

RIDGEFIELD, Conn. and INDIANAPOLIS, March 6, 2018 /PRNewswire/ — Boehringer Ingelheim and Eli Lilly and Company (NYSE: LLY) today announced plans to expand their clinical trial program for Jardiance® in chronic heart failure with the EMPERIAL clinical trials.

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Routine walking cuts heart failure risk by 25% for post-menopausal women

Post-menopausal women who go on exercise walks at least twice per week enjoy a 20 to 25 percent risk reduction for heart failure, according to research that will be presented March 12 at the American College of Cardiology’s annual scientific session in Orlando, Florida.

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Genetic testing for cardiomyopathy less accurate for minorities

Genetic testing for cardiomyopathy in the United States works significantly better for whites than minorities, according to a report published online Feb. 28 in JAMA Cardiology.

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