Heart Failure

Heart failure occurs when the heart cannot pump as much blood as the body requires. This ineffective pumping can lead to enlargement of the heart as the myocardium works harder pump the same amount of blood. Heart failure may be caused by defects in the myocardium, such as an a heart attack infarct, or due to structural issues such as severe heart valve regurgitation. Heart failure can be divided into HF with preserved ejection fraction (HFpEF), and HF with reduced ejection fraction (HFrEF). The disease is further divided into four New York Heart Association (NYHA) classes. Stage IV heart failure is when the heart is completely failing and requires a heart transplant or hemodynamic support from a left ventricular assist device (LVAD).

Thumbnail

Genomic blood test predicts survival for heart failure patients after MCS surgery

Researchers at UCLA have developed a blood test using gene activity data from immune cells that helps predict the survival of advanced heart failure patients receiving mechanical circulatory support (MCS) devices.

Thumbnail

Hispanics born abroad have higher CVD rates than US-born counterparts

Hispanic heart patients born abroad face a greater risk of dying from cardiovascular disease than their American-born counterparts, according to new research published in the Journal of the American Heart Association.

FDA grants fast track designation to Renova Therapeutics’ RT-100 AC6 gene transfer for the treatment of heart failure

San Diego, Calif. — Renova™ Therapeutics, a biotechnology company developing gene and peptide-based treatments for cardiovascular and metabolic diseases, announced today that the U.S. Food and Drug Administration (FDA) has granted Fast Track designation for the company’s lead product candidate, RT-100 AC6 gene transfer (Ad5.hAC6), for the treatment of heart failure with reduced ejection fraction (HFrEF).

Thumbnail

U.S. health rankings: Mississippi, other Southern states had highest CVD death rates in 2017

Cardiovascular deaths are up 2 percent from 2015 and have been identified as one of the fastest-growing health problems in the U.S., the United Health Foundation (UHF) reported this week in its 28th annual ranking report.

US flu season is on track to be a harsh one, officials say

The U.S. flu season could be uncharacteristically harsh this winter, NPR reported this month—and that could have serious consequences for heart patients.

Thumbnail

Johns Hopkins cardiologist diagnoses Grinch Who Stole Christmas' 'heart condition'

If you know the story, you know the stats—the eponymous character of Dr. Seuss’s "The Grinch Who Stole Christmas" starts the tale with a heart “two sizes too small” and ends it with one three times larger, thanks to Cindy Lou Who and her friends.

Thumbnail

Optimal drug dosing after heart failure extends patients’ careers

Patients who receive target or near-target doses of evidence-based medicine (EBM) are more likely to continue working after a heart failure hospitalization, according to a study of Danish individuals published Dec. 6 in JACC: Heart Failure.

Heart cell damage during non-cardiac surgery can be fatal, but often unnoticed

Damage inflicted during non-cardiac surgery can reach heart cells and significantly raise a patient’s risk of mortality for up to one year after the procedure, according to research published this week in the American Heart Association journal Circulation.

Around the web

Ron Blankstein, MD, professor of radiology, Harvard Medical School, explains the use of artificial intelligence to detect heart disease in non-cardiac CT exams.

Eleven medical societies have signed on to a consensus statement aimed at standardizing imaging for suspected cardiovascular infections.