Heart Rhythm

Hearts should have normal rhythm to their beats, but when these beats are out of synch, it causes inefficient pumping of blood. Irregular heart arrhythmias occur when the electrical signals that coordinate the heart's beats do not work properly. This can cause beats that are too fast (tachycardia), or too slow (bradycardia). Tachycardias include atrial fibrillation (AFib), supraventricular tachycardia, ventricular fibrillation, and ventricular tachycardia (VT). Bradycardias include sick sinus syndrome and conduction block. Electrophysiology arrhythmia treatments include medications, life style changes, and the EP lab interventions of catheter ablation, and implantable pacemakers or defibrillators.

New data from the Phase 3 RAPID clinical trial of etripamil, an investigational calcium channel blocker nasal spray, showed positive results in converting paroxysmal supraventricular tachycardia (PSVT) to normal sinus rhythm in the at-home setting. The presentation was featured during a late-breaking clinical trials session at the American Heart Association (AHA) 2022 Scientific Sessions. #AHA22

Etripamil nasal spray meets primary endpoint of terminating paroxysmal supraventricular tachycardia 

The drug allows patients to take control over their condition with self administration and the therapy and may help lower healthcare costs and resource utilization by keeping these patients out of emergency rooms. 

Jason Andrade, MD, FRCPC, FHRS, director of electrophysiology, Vancouver General Hospital, clinical associate professor, University of British Columbia, and principal investigator for the PROGRESSIVE AF trial, explains how cryoablation can be used as a front-line treatment for atrial fibrillation (AFib). He presented this late-breaking trial at the American Heart Association (AHA) 2022 meeting, which showed the therapy can be used instead of trying drug therapy first. #AHA22 #EPeeps

VIDEO: Cryoablation can be used as frontline therapy before drugs: PROGRESSIVE AF trial

Jason Andrade, MD, director of electrophysiology, Vancouver General Hospital, and principal investigator of the PROGRESSIVE AF trial, explains how cryoablation can be used as a frontline treatment for atrial fibrillation (AFib) before drugs in this AHA late-breaker. 

Medtronic’s Arctic Front cryoballoon catheters

Treating AFib early with cryoablation reduces risk of disease progression, repeat hospitalization

“The evidence shows increasingly that it’s time to rethink how we approach the treatment of AFib,” one researcher said.

A transcatheter aortic valve replacement (TAVR) procedure being performed at Intermountain Healthcare. Image from Intermountain Healthcare

Predictors of 1-year mortality after TAVR are significantly different among men and women

Atrial fibrillation and peripheral artery disease, for example, are both predictors of mortality among women, but not men. 

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AI-powered ECG screening boosts patient outcomes—when clinicians give it a chance

New research out of Mayo Clinic found that clinicians who listened to AI-based treatment recommendations were more successful at identifying patients with low ejection fraction. 

Cardiologists, electrophysiologists ‘disappointed’ in final 2023 Medicare Physician Fee Schedule

The American College of Cardiology and Heart Rhythm Society issued a joint statement soon after CMS published its final rule for the 2023 Medicare Physician Fee Schedule. The groups warned that the final rule could threaten patient access to high-quality care. 

David Bennett with two of his physical therapists at the University of Maryland Medical Center

ECG data from historic pig heart transplant surprise electrophysiologists

“This was a true milestone for research on xenotransplantation," one specialist said. The full analysis is scheduled to be presented at the American Heart Association's Scientific Sessions 2022 in Chicago.

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Dapagliflozin still beneficial for HFpEF, HFmrEF patients with AFib

While some heart failure medications are less effective in patients with concomitant atrial fibrillation, new research suggests that is not the case for dapagliflozin.

Around the web

Ron Blankstein, MD, professor of radiology, Harvard Medical School, explains the use of artificial intelligence to detect heart disease in non-cardiac CT exams.

Eleven medical societies have signed on to a consensus statement aimed at standardizing imaging for suspected cardiovascular infections.