Structural Heart Disease

Structural heart diseases include any issues preventing normal cardiovascular function due to damage or alteration to the anatomical components of the heart. This is caused by aging, advanced atherosclerosis, calcification, tissue degeneration, congenital heart defects and heart failure. The most commonly treated areas are the heart valves, in particular the mitral and aortic valves. These can be replaced through open heart surgery or using cath lab-based transcatheter valves or repairs to eliminate regurgitation due to faulty valve leaflets. This includes transcatheter aortic valve replacement (TAVR). Other common procedures include left atrial appendage (LAA) occlusion and closing congenital holes in the heart, such as PFO and ASD. A growing area includes transcatheter mitral repair or replacement and transcatheter tricuspid valve repair and replacement.

Louisiana AG sues GSK over Avandia

Louisiana Attorney General Buddy Caldwell, on behalf of the state, filed a civil action suit against GlaxoSmithKline (GSK), formerly SmithKline Beecham, claiming that the pharmaceutical maker wrongfully and illegally marketed, priced, sold and promoted the diabetes medication rosiglitazone, under the trade names Avandia, Avandamet and Avandaryl.

ACR trial to question necessity of SPECT in CAD treatment planning

The American College of Radiology (ACR) is launching a trial to determine whether patients with stable angina can safely undergo cardiac CT angiography (CCTA) to determine if plaque stenosis is the cause of their pain, instead of a SPECT myocardial perfusion imaging exam, that often is followed by invasive catheter angiography to assess the degree of coronary artery disease.

Mass. hits Novo Nordisk with subpoena over diabetes drugs

Novo Nordisk has been slapped with a subpoena from the U.S. Attorney for the District of Massachusetts that calls for the company to fork over documents regarding potential criminal offenses related to the companys marketing and promotion of diabetes products.

JAMA: Black, elderly patients see higher readmissions, overhaul needed

African-American and elderly Medicare recipients are more likely to be readmitted to the hospital after cases of acute MI, congestive heart failure and pneumonia when compared with whites, according to a study published in the Feb. 16 issue of the Journal of the American Medical Association.

Medicines nets up to $222M in Angiomax settlement with law firm

The Medicines Company has reached a settlement agreement with the law firm WilmerHale resolving all its potential claims against WilmerHale related to the principal U.S. patent covering the product bivalirudin (Angiomax), U.S. Patent No. 5,196,404 (the 404 patent).

Physio-Control, BeneChill to co-market portable hypothermia system

Physio-Control, a manufacturer of external defibrillation and monitoring technology, and BeneChill, makers of portable therapeutic cooling systems, have entered into a strategic partnership to launch the RhinoChill IntraNasal cooling system in Europe.

GSK updates Avandia labeling, based on FDA recommendations

GlaxoSmithKline (GSK) has revised the U.S. prescribing information and medication guides for rosiglitazone-containing medicines (Avandia, Avandamet and Avandaryl) to include additional safety information and restrictions on the use of these medicines, reflecting the FDAs review of cardiovascular event data in type 2 diabetes patients treated with Avandia.

Court maintains Medtronic owes Edwards $74M over CoreValve patent

The U.S. District Court for the District of Delaware reaffirmed an April 2010 federal jury decision that determined Medtronic CoreValve willfully infringed Edwards Lifesciences Andersen transcatheter heart valve patent and awarded Edwards $74 million in damages.

Around the web

Several key trends were evident at the Radiological Society of North America 2024 meeting, including new CT and MR technology and evolving adoption of artificial intelligence.

Ron Blankstein, MD, professor of radiology, Harvard Medical School, explains the use of artificial intelligence to detect heart disease in non-cardiac CT exams.