Structural Heart Disease

Structural heart diseases include any issues preventing normal cardiovascular function due to damage or alteration to the anatomical components of the heart. This is caused by aging, advanced atherosclerosis, calcification, tissue degeneration, congenital heart defects and heart failure. The most commonly treated areas are the heart valves, in particular the mitral and aortic valves. These can be replaced through open heart surgery or using cath lab-based transcatheter valves or repairs to eliminate regurgitation due to faulty valve leaflets. This includes transcatheter aortic valve replacement (TAVR). Other common procedures include left atrial appendage (LAA) occlusion and closing congenital holes in the heart, such as PFO and ASD. A growing area includes transcatheter mitral repair or replacement and transcatheter tricuspid valve repair and replacement.

JACC: Are the JUPITER recommendations for statin use really cost effective?

Rosuvastatin treatment for JUPITER-eligible patients appears to be cost effective, particularly among those with a Framingham risk score of 10 percent or greater, based on a substudy by the JUPITER researchers, which was published Feb. 15 in the Journal of the American College of Cardiology. However, the accompanying commentary questioned whether the cost associated with the millions of increased statin users, based on the JUPITER researchers' recommendations, is "the best use" of today's "healthcare dollars?"

BMJ: P4P doesn't yield better hypertension outcomes

A new study published Jan. 26 in the British Medical Journal (BMJ) presents strong evidence that pay-for-performance (P4P) does not offer any benefit to patients with hypertension, despite the enormous administrative costs required to maintain such a system.

Declining Lipitor sales hurt Pfizers FY10 net income

Despite posting a very strong 2010 fourth quarter, Pfizer reported losses for its income in the fiscal year of 2010, which were somewhat negatively impacted by declining sales of atorvastatin (Lipitor).

Arena to slash 25% of workforce, will continue fight for lorcaserin

Arena Pharmaceuticals is planning to slash 66 employees from its workforce; however, the company said it will continue its fight with the FDA to gain regulatory approval for its obesity drug lorcaserin.

Meta-analysis suggests statins not effective for low-risk patients

There is not enough evidence to use statins for primary prevention in those at low risk of cardiovascular disease. In addition, studies examining primary prevention need to be better designed, according to a meta-analysis by The Cochrane Collaboration published in January.

Lancet: Statins are effective, regardless of CRP levels

Statins are at least as effective in patients with low levels of inflammation as they are in other patients, according to a study from the Heart Protection Study Collaborative Group published online Jan. 27 in the Lancet. These findings refute the suggestion that a person's level of systemic inflammation, as measured by levels of C-reactive protein (CRP), could modify their response to statin therapy.

St. Jude's CRM, a-fib arms propel its returns for Q4, FY10

St. Jude Medical has reported positive sales and net earnings for the fourth quarter and year, which ended Jan. 1, and were bolstered by increased profits in its cardiac rhythm management (CRM) and atrial fibrillation segments.

CMAJ: Restricting ARB use could have saved Canada $77M

If Canada adopted a more restrictive policy on administering ARBs that did not negatively affect cardiovascular health, the country could have saved the healthcare system $77 million in 2006, according to a study published in the January issue of the Canadian Medical Association Journal.

Around the web

Several key trends were evident at the Radiological Society of North America 2024 meeting, including new CT and MR technology and evolving adoption of artificial intelligence.

Ron Blankstein, MD, professor of radiology, Harvard Medical School, explains the use of artificial intelligence to detect heart disease in non-cardiac CT exams.