Structural Heart Disease

Structural heart diseases include any issues preventing normal cardiovascular function due to damage or alteration to the anatomical components of the heart. This is caused by aging, advanced atherosclerosis, calcification, tissue degeneration, congenital heart defects and heart failure. The most commonly treated areas are the heart valves, in particular the mitral and aortic valves. These can be replaced through open heart surgery or using cath lab-based transcatheter valves or repairs to eliminate regurgitation due to faulty valve leaflets. This includes transcatheter aortic valve replacement (TAVR). Other common procedures include left atrial appendage (LAA) occlusion and closing congenital holes in the heart, such as PFO and ASD. A growing area includes transcatheter mitral repair or replacement and transcatheter tricuspid valve repair and replacement.

JCH: Cost effectiveness of blood pressure device uncertain

In addition to lowering blood pressure, the implantable carotid body stimulator Rheos (CVRx, Minneapolis) may be economical, with an incremental cost-effectiveness ratio between $50,000 and $100,000 per quality-adjusted life-years, according to a study in this months Journal of Clinical Hypertension.

Galapagos may get $600M in expanded Merck deal for atherosclerosis

Galapagos has expanded its global strategic alliance in metabolic diseases with an affiliate of Merck to incorporate the development of new therapies for atherosclerosis.

Baxter books positive Q3

Baxter International has positive financial results for the third quarter of 2009, which ended Sept. 31.

Pfizer completes $68B acquisition of Wyeth

Pfizer has completed its acquisition of Wyeth following the receipt of regulatory approval from all government authorities required by the merger agreement and approval by Wyeth shareholders.

Medicines sues generic drugmakers over Angiomax patent

The Medicines Company has filed lawsuits against Teva Parenteral Medicines, Pliva Hrvatska and APP Pharmaceuticals over Angiomax (bivalirudin) patent infringement.

Edwards to open new manufacturing, R&D facility in Utah

Edwards Lifesciences, a developer of heart valves and hemodynamic monitoring products, is developing a new manufacturing facility in Draper, Utah, which will enable the company to expand its manufacturing and R&D capability.

Report: Stronger U.S. pharma sales will lead 2010 global market to $825M

The value of the global pharmaceutical market in 2010, driven by stronger near-term growth in the U.S. market, is expected to grow 4-6 percent on a constant-dollar basis, exceeding $825 billion, according to report from market research firm IMS Health.

TCT: Physio-Control touts battery-powered CPR device

For years, the Lucas automated chest compression device was powered only pneumatically. However, the company now released the Lucas 2 with a lithium ion polymer battery that lasts up to 45 minutes, which was showcased at the 21st annual Transcatheter Cardiovascular Therapeutics (TCT) conference.

Around the web

Ron Blankstein, MD, professor of radiology, Harvard Medical School, explains the use of artificial intelligence to detect heart disease in non-cardiac CT exams.

Eleven medical societies have signed on to a consensus statement aimed at standardizing imaging for suspected cardiovascular infections.

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