Heart Failure

Heart failure occurs when the heart cannot pump as much blood as the body requires. This ineffective pumping can lead to enlargement of the heart as the myocardium works harder pump the same amount of blood. Heart failure may be caused by defects in the myocardium, such as an a heart attack infarct, or due to structural issues such as severe heart valve regurgitation. Heart failure can be divided into HF with preserved ejection fraction (HFpEF), and HF with reduced ejection fraction (HFrEF). The disease is further divided into four New York Heart Association (NYHA) classes. Stage IV heart failure is when the heart is completely failing and requires a heart transplant or hemodynamic support from a left ventricular assist device (LVAD).

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LVAD recipients see heightened risk of suicide

Heart patients with implanted left ventricular assist devices are more likely to both attempt and succeed in committing suicide than other chronically ill patients, according to a study out of France.

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Pop Goes the Pillbox: Will Polypharmacy Problems Limit the Adoption of SGLT2 Inhibitors?

Following data supporting their use for heart failure and type 2 diabetes, will sodium-glucose cotransporter 2 inhibitors find a spot in the heart failure armamentarium?

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Ablation continues to benefit patients with concomitant HF, AFib

A new analysis of the CASTLE-AF trial has found that catheter ablation for AFib remains effective in a much larger group of heart failure patients, cementing evidence first presented in early 2018.

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Researchers ID new protein as contributor to sudden cardiac death

A small-scale study published in Circulation March 3 has revealed a potential new culprit behind sudden cardiac death in patients with arrhythmogenic right ventricular cardiomyopathy: integrin β1D.

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Opioid use disorder meds boost odds of recovery in endocarditis patients

Drugs used to treat opioid use disorder may also be successful in improving the health outcomes of patients admitted to the hospital for injection drug use-associated endocarditis, according to research out of Boston.

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AI-powered wearable predicts HF rehospitalizations 10 days ahead of time

A wearable sensor developed by researchers at University of Utah Health and VA Salt Lake City Health Care System has the potential to predict heart failure complications more than a week before they occur.

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America’s most expensive CV drug needs a 93% price cut

A 92.6% reduction in the list price of tafamidis—an effective but ultimately unaffordable drug designed to treat transthyretin amyloid cardiomyopathy—would be required to make the medication accessible to the average heart patient, researchers reported in Circulation Feb. 12.

FDA delayed reporting, recalling faulty HF pacemaker for more than 1 year

Medtronic and the FDA were both aware of battery and wire connection defects in a now-recalled heart failure pacemaker for over a year before patients developed serious side effects, according to a report published in JAMA Internal Medicine.

Around the web

Ron Blankstein, MD, professor of radiology, Harvard Medical School, explains the use of artificial intelligence to detect heart disease in non-cardiac CT exams.

Eleven medical societies have signed on to a consensus statement aimed at standardizing imaging for suspected cardiovascular infections.