Heart Failure

Heart failure occurs when the heart cannot pump as much blood as the body requires. This ineffective pumping can lead to enlargement of the heart as the myocardium works harder pump the same amount of blood. Heart failure may be caused by defects in the myocardium, such as an a heart attack infarct, or due to structural issues such as severe heart valve regurgitation. Heart failure can be divided into HF with preserved ejection fraction (HFpEF), and HF with reduced ejection fraction (HFrEF). The disease is further divided into four New York Heart Association (NYHA) classes. Stage IV heart failure is when the heart is completely failing and requires a heart transplant or hemodynamic support from a left ventricular assist device (LVAD).

FDA OKs Pfizer’s tafamidis to treat cardiac amyloidosis

The FDA has cleared two new drugs, tafamidis and tafamidis meglumine, for the treatment of cardiomyopathy caused by a rare disorder known as transthyretin-mediated amyloidosis (ATTR-CM).

Viagra-like sex drug also effective as HF therapy

Research out of the University of Manchester suggests Tadalafil (Cialis)—an erectile dysfunction drug that falls in the same class as Viagra—could slow and possibly reverse the progression of heart failure (HF).

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Rivaroxaban plus standard therapy reduces thromboembolic events in HF, CAD patients

Five milligrams of rivaroxaban per day added to a patient’s standard therapy for heart failure (HF) and coronary artery disease (CAD) could reduce that patient’s risk of future thromboembolic events, researchers reported in JAMA Cardiology April 24.

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Genetic variant linked to chemotherapy-induced cardiomyopathy

The same genetic variants that have been uncovered in patients with two other types of cardiomyopathy are also present in an uncommonly high proportion of people with cancer therapy-induced cardiomyopathy (CCM), researchers reported in Circulation.

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Scientists 3D-print world’s first heart with cells, blood vessels

Researchers at Tel Aviv University in Israel have 3D-printed what they said is the first vascularized heart using a patient’s own cells and biological materials.

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Socioeconomic factors may impact the chances of getting an LVAD

A study of nearly 900,000 patients with heart failure or cardiogenic shock revealed their race, insurance coverage and ZIP code were associated with their odds of receiving a left ventricular assist device (LVAD).

Apixaban linked to best outcomes in older patients with AFib, heart failure

Compared to warfarin, all direct oral anticoagulants (DOACs) were associated with fewer cardiovascular events including heart attacks and strokes in a study of Medicare patients with both nonvalvular atrial fibrillation and heart failure. But apixaban appeared to offer the best balance of protecting against these events while minimizing bleeding risk.

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Heart failure hospitalizations jump during flu season

In the latest study to link influenza and cardiovascular disease, researchers found that the most severe flu seasons coincided with spikes in hospitalizations for heart failure.

Around the web

Ron Blankstein, MD, professor of radiology, Harvard Medical School, explains the use of artificial intelligence to detect heart disease in non-cardiac CT exams.

Eleven medical societies have signed on to a consensus statement aimed at standardizing imaging for suspected cardiovascular infections.