Heart Failure

Heart failure occurs when the heart cannot pump as much blood as the body requires. This ineffective pumping can lead to enlargement of the heart as the myocardium works harder pump the same amount of blood. Heart failure may be caused by defects in the myocardium, such as an a heart attack infarct, or due to structural issues such as severe heart valve regurgitation. Heart failure can be divided into HF with preserved ejection fraction (HFpEF), and HF with reduced ejection fraction (HFrEF). The disease is further divided into four New York Heart Association (NYHA) classes. Stage IV heart failure is when the heart is completely failing and requires a heart transplant or hemodynamic support from a left ventricular assist device (LVAD).

Cotton vest aims to predict, prevent MI in CHF patients

A French health tech company debuted its Chronolife vest—a cotton- and lycra-based wearable aimed at preventing medical emergencies in patients with chronic or congestive heart failure (CHF)—at CES 2019 in Las Vegas on Jan. 6, CNET reported.

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Back-to-back triple transplant recipients spark friendship at Chicago hospital

University of Chicago Medicine physicians performed the 16th and 17th triple transplant surgeries in the United States within 30 hours of each other in late December, giving two different patients a healthy heart, kidney and liver all at once.

After COAPT: Getting MitraClip Right in the Real World

Will operators be able to replicate COAPT’s restraint and its outcomes?

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AFib ablation boosts clinical outcomes for heart failure patients

Compared to drug therapy alone, catheter ablation nearly halved the risk of death and improved a range of clinical outcomes for patients with both heart failure and atrial fibrillation (AFib) in a meta-analysis.

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Metformin shows promise as treatment for HFpEF

Popular anti-diabetes drug metformin could have positive implications for heart failure patients, too, according to a recent study that found the medication reduced left ventricular stiffness in mice with heart failure with preserved ejection fraction (HFpEF).

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Heart failure outcomes remain steady in US

Although efforts to reduce heart failure (HF)-related deaths and readmissions in the United States were successful in the early 2000s, rates of HF-related ER visits, comorbid hospitalizations and mortality are at a standstill in 2018, according to a nationwide study published Dec. 11 in Circulation: Heart Failure.

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Baboons survived months with transplanted pig hearts. Could humans do the same?

Two baboons recently survived for six months following the transplantation of genetically modified pig hearts, bringing scientists closer to potentially using animal organs for humans who need transplants.

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Gene editing process leads to personalized advice for heart patient

University of Pennsylvania researchers have developed a stem cell-based test to determine whether genetic variants in heart muscle cells are benign or pathogenic. In other words, they’ve added some certainty to variants of uncertain significance—the tricky alleles that can either contribute to the development of diseases or be completely harmless.

Around the web

Ron Blankstein, MD, professor of radiology, Harvard Medical School, explains the use of artificial intelligence to detect heart disease in non-cardiac CT exams.

Eleven medical societies have signed on to a consensus statement aimed at standardizing imaging for suspected cardiovascular infections.