Pharmaceutics

This page contains key pharmaceutical news on drug recalls, FDA clearance, safety communications and research. In cardiology, key pharmaceutic agents include antiplatelet therapies, anticoagulants, hypertension drugs, and drugs for heart failure and arrhythmias.   

Dual antiplatelet therapy after CABG linked to a key benefit—and a key risk

A two-medication strategy after CABG surgery reduces the risk that grafts will fail, but it also increases the risk of serious bleeding. As one surgeon said, "the benefit comes at a price.”

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Very low doses of edoxaban are safe and effective for frail, elderly AFib patients

Elderly patients are often not eligible for oral anticoagulant therapy due to the risk of bleeding events or other adverse outcomes. A very low dose of edoxaban, however, appears to be a safe treatment option, even for especially frail patients.

Valentin Fuster, MD, PhD, director of Mount Sinai Heart and general director of the Spanish National Center for Cardiovascular Research

Polypill strategy improves odds of survival after a heart attack

The new findings, presented during ESC Congress 2022 and published in the New England Journal of Medicine, suggest that prescribing these new-look pills to heart patients could boost outcomes while also improving medication adherence.

USPSTF highlights the benefits of statin use among high-risk CVD patients in new recommendations

The USPSTF recommends statin use for high-risk patients between the ages of 40 to 75 to help prevent a first heart attack or stroke. Other patients in that same age group may also benefit, the group noted, but physician input is needed. 

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NSAID use may not be safe for older patients with type 2 diabetes

The new analysis, based on data from more than 330,000 patients, is scheduled to be presented during ESC Congress 2022. 

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Medical marijuana linked to a higher risk of heart rhythm issues

The new analysis, presented at ESC Congress 2022, found that a medical marijuana prescription for chronic pain may increase a person's overall arrhythmia risk. 

Merck Januvia Janumet Steglujan Nitroso-STG-19 (NTTP) type 2 diabetes

Possible carcinogen detected in multiple type 2 diabetes medications

To avoid a potential shortage, FDA officials have said the medications can be sold to patients on a temporary basis. 

SAPT after TAVR preferred over DAPT, new meta-analysis confirms

An international team of researchers, led by specialists from Cleveland Clinic, found that DAPT was consistently linked to a greater risk of major or life-threatening bleeding events. 

Around the web

Ron Blankstein, MD, professor of radiology, Harvard Medical School, explains the use of artificial intelligence to detect heart disease in non-cardiac CT exams.

Eleven medical societies have signed on to a consensus statement aimed at standardizing imaging for suspected cardiovascular infections.

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